"Blacksnake Blues" is the story of Karen Blacksnake, a Navajo woman who was abducted by the mob and set to work in its sex slave industry. Five years pass when she makes her daring escape, killing her client in the process. Now wanted by the FBI and the mob, she gains the aide of an eight-year-old homeless black girl, Raxi Malcom and her sister Zeebee. Together they must find rescue and remain on the run if they are to continue their flight from those who are hunting them down.
Living on the Navajo reservation, Karen Blacksnake is lured to The Well of Light Institute, the mob's phony modeling school and spiritual center in Sedona Arizona, where she is promised a career path to Hollywood. Instead, with other Indigenous women, she is abducted and put to work on a ship as a sex slave servicing libidinous billionaires on Lake Michigan. After her escape, Karen, Raxi and Zeebee are given sanctuary at the Convent of St. Mechtilde's on the Lake, where the Mother Superior, a radical mystic from Trinidad, has the power to charm snakes. Joined there by Tildey and Carmella they all set off on their ultimate journey. From the Convent of St. Mechtilde's all the way back to Arizona, it is a story of power and triumph. Uncover the insidious players who pull strings from the shadows, witness how Girl Power can overthrow the patriarchy's inevitable ineptitude, and struggle to win in a battle for the survival of the planet.